Ascending arousal network connectivity during recovery from traumatic coma

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Ascending arousal network connectivity during recovery from traumatic coma
Ascending arousal network connectivity during recovery from traumatic coma
  •   dataset_description.json
  •   README
  • sub-TCRc007
  • sub-TCRc008
  • sub-TCRc010
  • sub-TCRc011
  • sub-TCRc012
  • sub-TCRc013
  • sub-TCRc014
  • sub-TCRc015
  • sub-TCRc016
  • sub-TCRc017
  • sub-TCRc018
  • sub-TCRc019
  • sub-TCRc020
  • sub-TCRc021
  • sub-TCRc022
  • sub-TCRc023
  • sub-TCRp001
  • sub-TCRp002
  • sub-TCRp003
  • sub-TCRp005
  • sub-TCRp006
  • sub-TCRp007
  • sub-TCRp008
  • sub-TCRp009
  • sub-TCRp010
  • sub-TCRp011
  • sub-TCRp012
  • sub-TCRp013
  • sub-TCRp014
  • sub-TCRp015
  • sub-TCRp016
  • sub-TCRp017
  • sub-TCRp018
  • sub-TCRp019
  • sub-TCRp020
  • sub-TCRp021
  • sub-TCRp022
  • sub-TCRp023
  • sub-TCRp024
  • sub-TCRp025



CITATION: Snider SB, Bodien YG, Frau-Pascual A, Bianciardi M, Foulkes AS, Edlow BL. Ascending arousal network connectivity during recovery from traumatic coma. NeuroImage:Clinical. 2020; in press. PMCID pending.

EXPERIMENT Our goal was to identify the connections with the ascending arousal network with 1) the largest change during recovery of consciousness after a TBI and 2) had the largest connectivity differences between subjects with or without a chronic disorder of consciousness.

We pulled from a dataset of N = 18 subjects with acute severe TBI and coma(GCS <= 6, no eye opening for 24 hours, abnormal CT scan). 2 subjects (sub-TCRp014, sub-TCRp016) died during the acute hospitalization and were excluded from analyses in the manuscript above. All others recovered consciousness. 9 subjects had follow-up imaging >= 5 months after the initial hospitalization, while 7 subjects did not.

For comparison, we included N = 16 age,sex-matched control subjects and a convenience sample of N = 6 subjects with a chronic disorder of consciousness (DoC) >= 5 months following their TBI.

DATA Data included herein at this time only include the HARDI volumes, skull-stripped (bet2) for deidentification.

Acquired on 3T Skyra (Siemens) using 32-channel head coil. HARDI scan params: 2mm isotropic resolution, 60 diffusion encoding directions, 10 b0 volumes, b=2000 sec/mm2.

SUBJECT GROUPINGS TBI recovery patients, longitudinal imaging(N = 9): sub-TCRp001 ses-early ses-late sub-TCRp003 ses-early ses-late sub-TCRp005 ses-early ses-late sub-TCRp006 ses-early ses-late sub-TCRp008 ses-early ses-late sub-TCRp013 ses-early ses-late sub-TCRp017 ses-early ses-late sub-TCRp018 ses-early ses-late sub-TCRp023 ses-early ses-late

TBI patients, acute imaging only(N = 9) sub-TCRp007 ses-early sub-TCRp009 ses-early sub-TCRp010 ses-early sub-TCRp011 ses-early sub-TCRp012 ses-early sub-TCRp014 ses-early sub-TCRp015 ses-early sub-TCRp016 ses-early sub-TCRp022 ses-early

Chronic DOC (N = 6): sub-TCRp002 ses-late sub-TCRp019 ses-late sub-TCRp020 ses-late sub-TCRp021 ses-late sub-TCRp024 ses-late sub-TCRp025 ses-late

Age/Sex-matched healthy controls (N = 16): sub-TCRc* ses-1


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