This dataset contains reconstructed, unprocessed MRI data accompanying the paper titled "Deciphering the scopolamine challenge rat model by preclinical functional MRI". Experiment 1 was conducted on subjects 1-18, and experiment 2 on subjects 19-34. Each rat underwent multiple sessions (3 and 4 sessions in experiment 1 and 2 respectively) and were pretreated with either i.p. scopolamine, butylscopolamine, donepezil (only in experiment 2), or saline buffer in a randomized cross-over design. They were anesthetised in either isoflurane or in a combination of isoflurane and i.p. medetomidine. For functional assessment, whisker stimulation was used with an air puff aimed at the right whisker pad. Functional scans were acquired with either gradient echo EPI, spin echo EPI or multislice FAIR-ASL. Resting state scans were also acquired but are not discussed in the paper. While we publish this dataset as one BIDS project, it is recommended to slice this dataset into 2 BIDS compatible datasets and handle the 2 experiments separetely during processing, as there are substantial differences (eg.: number of sessions, sequences).