The SUDMEX_CONN dataset is the result of a case-control study of cocaine use disorder patients. The study was done at the National Institute of Psychiatry in Mexico City by PIs Dr. Eduardo A. Garza-Villarreal and Jorge J. Gonzalez Olvera. The MRI sequences were: 1) T1-weighted, 2) rsfMRI 10 min, 3) HARDI-DWI multishell. Full clinical data will be uploaded to Zenodo soon. This is the first official release.